Every evening, gently smooth over cleansed face and neck in an upward and outward motion avoiding eyelids. Some individuals, especially those with sensitive skin, may feel a brief tingling sensation after application. If this occurs, wait 15 minutes after cleansing or try using the product more sparingly or less frequently, until your skin accommodates. Those with delicate or unusually sensitive skin may not be comfortable using this product. Wait until fully absorbed before applying makeup. Recommended to use as regimen with other Anew products for optimal results.